| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
A 3D printed PLCL/dECM hydrogel complex for adipose tissue engineering. |
| 초록 |
Adipose tissue regeneration has been studied, however, many disadvantages such as fast degradation rate and mismatch of mechanical properties still exist. So we set up several strategies to overcome these limits. Poly (L-lactide-co-ε-caprolactone) (PLCL) was synthesized to provide proper mechanical properties and a stable tertiary structure. Decellularized extracellular matrix (dECM) was used to promote angiogenesis for efficient blood supply. 3D printing was used to fabricate a patient-specific scaffold. The PLCL and hydrogel was printed through dual nozzle system. Flexibility and stretchability of the PLCL were maintained after 3D printing. In vivo experiments were conducted to investigate the potential for adipose tissue regeneration (PLCL only, PLCL-Hydrogel complex). We evaluated the mechanical properties, morphologies and gene expression level for scaffold characterization. We expected our constructs will be a promising alternative for adipose tissue regeneration. |
| 저자 |
이수진1, 정지홍2, 김수현2, 이강원1, 정영미2
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| 소속 |
1서울대, 2한국과학기술(연) |
| 키워드 |
3D printing; polymer; PLCL; dECM
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| E-Mail |
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