| 초록 |
Biodegradable and pH-sensitive graft copolymer polyaspartamide derivatives were synthesized by grafting of octadecylamine (C18), hydrazine hydrate and O-(2-Aminoethyl)polyethylene glycol 5000 on polysuccinimide. And PEG was grafted to biotin acted as ligand. These features make higher drug delivery efficiency. The chemical structure of the polymer and the degree of substitution of the prepared polymer was confirmed using FT-IR, 1H NMR spectroscopy. The Size of polymer micelles was confirmed to dynamic light scattering (DLS) and transmission electron microscopy (TEM). Intracellular release behaviors of micelles are followed with confocal laser scanning microscopy (CLSM). And this polymeric micelles directly go inside the cells and more effectively deliver drugs. |
