| 초록 |
Calcium phosphate mineralization of self-assembled nanotemplates can produce biocompatible, robust nanocarriers that can specifically release drugs in acidic cellular endo/lysosomes. In this study, we describe the potential of mineralized nanoparticles for photodynamic therapy of tumors. The core-shell-corona polymer micelles of poly(ethylene glycol)poly(L-aspartic acid)poly(L-phenylalanine) (PEG-PAsp-PPhe) was utilized as a nanotemplate for calcium phosphate mineralization. Especially, PAsp middle shells with anionic carboxylate charges serve as a template for mineralization to deposit inorganic calcium phosphate, which can protect efficiently the release of photosensitizer at extracelluar environments (pH 7.4) and can dissolve in endosomal compartments (pH 5.0) to facilitate the intracellular release of photosensitizers. This novel hybrid photosensitizer-encapsulated nanocarrier may show the effective photodynamic therapeutic efficacy for various tumors. |
