| 초록 |
In this study, the robust nanocarriers were developed by calcium phosphate mineralization on PEG-b-polyaspartate-b-polyphenylalanine polymer micelles for effective anticancer drug delivery. Cy5.5, a NIRF dye, was conjugated with polymer micelles to monitor their in vivo biodistibution. The mineralized could minimize the loss of the entrapped doxorubicin (DOX) before reaching target tissues, and selectively dissolve in lower pH and Ca2+ concentration of endosomal compartments to facilitate intracellular drug release. The optical imaging results indicated that Cy5.5-labeled hybrid nanocarriers showed the prolonged circulation time in blood and enhanced tumor specificity in tumor-bearing mice, due to the stability of mineralized micelles and enhanced permeation and retention (EPR) effect. To assess in vivo therapeutic efficacy, we performed the tumor volume monitoring for tumor-bearing mice. The growth of tumors was remarkably inhibited, as compared with control groups. |
