| 초록 |
Conjugated polymer nanoparticles can be easily prepared using aromatic dialdehydes and diacetonitriles via in situ colloidal Knoevenagel polymerization. These particles generate bright fluorescence in the near-infrared region, being allowed for in vivo imaging. However, their application to bioimaging was limited to sentinel lymph node mapping due to their negative surface charges and no functional groups for further functionalization. Here, we modified the surface of conjugated polymer nanoparticles using PS-binding peptides and bio-polymer. Because the nanoparticles consist of cyanovynylene-based polymers, PS-binding peptides could be interacted with the surface of the nanoparticles by π-π stacking and van der Waals force. Using the functional groups in the peptide, polyethylene glycol and cancer targeting ligand were conjugated on the nanoparticles for bioimaging. |
