| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Low-bandgap Polymer Blended Biophotonic Nanoplatform |
| 초록 |
Photonic nanomaterials have found wide applications in theranostics. We introduce here a design of all-organic photonic nanoparticles, different from traditional ones, in which we utilize nanoblend of a low-bandgap-conjugated polymer (LB-CP) and polystyrene as the photonic core, surrounded by an FDA-approved polymeric surfactant. These biophotonic nanoblend particles (~20 nm in diameter) show facile blood circulation, efficient disease targeting and minimal liver filtration as well as sustained renal excretion in the intravenously administered mouse models, as noninvasively visualized by the NIR emission signals. In diseased mouse models, pathological tissue deoxygenation at hypoxic sites was successfully detected with ratiometric spectral information. We also show that our nanoformulation exhibits no apparent toxicity, thus serving as a versatile biophotonics platform for diagnostic imaging. |
| 저자 |
서영훈1, 조민주2, 장우동3, 최동훈2, 김세훈1
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| 소속 |
1한국과학기술(연), 2고려대, 3연세대 |
| 키워드 |
low-bandgap conjugated polymer; imaging nanoplatform; biomedical imaging
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| E-Mail |
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