| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.442 |
| 발표분야 | 기능성 고분자 |
| 제목 | Kinetics of the ring-opening polymerization of ε-caprolactone and L-lactide initiated by poly(ethylene glycol) |
| 초록 | Biodegradable polyesters such as ε-caprolactone (ε-CL) and L-lactide (LA) is an attractive polymer which can be used as a synthetic biomaterial or controlled drug release matrix due to its good biodegradability and biocompatibility. Poly(ethylene glycol) presents outstanding physico-chemical and biological properties, including higher hydrophilicity, solubility in water, lack of toxicity, absence of antigenicity and immunogenicity. The existing polymerization method spent for many hours and obtained broad dispersity index in PEG-PCLA copolymers. In this study, to examine the time, temperature, and catalyst dependence for ε-caprolactone and L-lactide conversion, the polymerization of ε-caprolactone and L-lactide was carried out with MPEG(Mn: 750 g/mol) in presence of Sn(Oct)2 at 90-130℃ for 1-3h. MPEG-PCLA copolymers were characterized by 1H NMR and GPC to confirm molecular weight and polydispersity index. The molecular weight of MPEG-PCLA copolymers in each case showed inceasing tendency according to polymerization time and temperature. However, the more incease amount of catalyst, the lower increase ratio of molecular weight with the polymerization time because of reversible chain transfer in 130℃. Also polydispersity index was inceased in amount of each catalyst with regard to increase polymerization time and temperature. Similarly, the more increase amount of catalyst, the more decrease polydispersity index with the polymerization time. In conclusion, We obtained the MPEG-PCLA copolymers with narrow polydispersity index within 1.5 and the desired mloecular weight that controlled properly amount of catalyst and polymerization time in this study. Acknowledgement : This work was supported by KMOHW (0405-BO01-0204-036). References 1. A. Albertsson, and I. K. Varma, Recent developments in ring opening polymerization of lactones for biomedical applications, Biomacromolecules, 4, 1466 (2003). 2. L. Zhang, C. C. Chu, and I. H. Loh, Effect of a combined gamma irradiation and parylene plasma treatment on the hydrolytic degradation of synthetic biodegradable sutures, J. Biomed. Mater. Res., 27, 1425 (1993). |
| 저자 | 현훈1, 서광수1, 김문석2, 조선행2, 강길선1, 이해방2 |
| 소속 | 1전북대, 2한국화학(연) |
| 키워드 | Kinetics; caprolactone; lactide; ring-opening |
