| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Fabrication and characterization of PLGA polymer-lipid hybrid nanoparticle for gene delivery platform |
| 초록 |
The major problem in the field of cell therapy is how to effectively deliver target genes to special cells. In this study, we aimed to develop a poly (D, L-lactide-co-glycolide) (PLGA)-lipid hybrid nanoparticles (NP) for gene delivery, which has the ability to overcome the disadvantages of polyethylenimine (PEI) - or cationic liposome based gene carrier. The PLGA polymer-lipid NP were successfully fabricated by emulsion solvent evaporation method and characterized by scanning electron microscopy, dynamic light scattering. Plasmid EGFP gene as a model gene was complexed with NP (100-200nm) and then transfected to 293 cells. Therefore, PLGA polymer-lipid hybrid nanoparticles would be widely utilized as a promising non-viral carrier for the delivery of genes as well as drugs. |
| 저자 |
Rajendran Jagathesh chandra Bose1, 안종찬2, 이수홍2, 박한수2
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| 소속 |
1중앙대, 2차의과학대 |
| 키워드 |
hybrid nanoparticle; Gene delivery
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| E-Mail |
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