| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Development of Zwitterionic Polyurethane additives possessing anti-fouling effect for Implantable Medical Device Applications |
| 초록 |
Thrombus formation and infection are problems in implantable medical device development. Polyurethanes (PUs) have been used in various medical device field due to their biocompatibility, flexibility, and thermal stability. In this study, we designed a novel anti-thrombogenic and anti-microbial PUs by modification with various additives. The zwitterionic groups were grafted on the PUs backbone. These prepared zwitterionic PUs were characterized using 1H-NMR, FTIR, and element analysis. All results indicate that both zwitterionic side chains and anti-bacterial end-groups were successfully introduced into the PUs backbone. The surface properties of various base-polymers such as PU, PLGA, and PVC with and without zwitterionic PUs were identified using water contact angle measurement. We also investigated human fibrinogen and bovine serum albumin antifouling effect of prepared additives after mixing with base-polymers. The anti-microbial effect of zwitterionic PUs will also be confirmed. |
| 저자 |
가동헌1, 정윤기1, 한동근2, 박성빈1, 손태일2
|
| 소속 |
1KIST, 2한국기술연합대 |
| 키워드 |
Zwitterionic polyurethane; Anti-thrombosis; Anti-bacterial materials; Antifouling; Medical device
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| E-Mail |
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