| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Nano-Sized Ionic Complex Based on Insulin and Glycol Chitosan as a Potential Therapeutics for Type I Diabetes |
| 초록 |
Glycol chitosan (GC) and its derivative bearing a hydrophobic moiety were investigated as the potential carrier for the protein drug, insulin. Both of GC and its derivative could form stable nano-sized complexes with insulin via the ionic interactions. The complex had a size in the range of 100-500 nm, depending on the weight ratio of the polymer and insulin. The biological activity of the insulin in the complex was comparable to that of native insulin, indicating that the complex formation does not affect the biological activity of insulin. From in vivo results, it was demonstrated that, when subcutaneously injected into the streptozotocin-induced type I diabetic mice, the nanocomplexes effectively decreased the blood glucose level for the longer period of time than native insulin. Overall, the nanocomplexes, prepared in this study, might be useful as the therapeutics for type I diabetes. |
| 저자 |
조형곤1, 이슬기2, 김광명2, 박재형1, 권익찬2, 정서영1
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| 소속 |
1경희대, 2KIST 의과학연구센터 |
| 키워드 |
Glycol chitosan(GC); GC derivative; nanocomplex; insulin
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| E-Mail |
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