| 학회 |
한국화학공학회 |
| 학술대회 |
2007년 가을 (10/26 ~ 10/27, 한국과학기술원) |
| 권호 |
13권 2호, p.2319 |
| 발표분야 |
재료 |
| 제목 |
Multifunctional Magnetic Gold Nanocomposites: Cancer Detection via Magnetic Resonance Imaging and Localized Synchronous Therapy |
| 초록 |
Novel multifunctional magnetic gold nanocomposites (MGNCs) were synthesized for synchronous cancer therapy and diagnosis via magnetic resonance imaging (MRI). The MGNCs consist of magnetic kernels (MKs: aggregates of ultra-sensitive MnFe2O4 magnetic nanocrystals wrapped in polymer) as effective MR contrast agents and silica-gold nanocomposites as hyperthermal therapeutic agents. Erbitux (ERB)-conjugated MGNCs selectively recognized the target cancer cell lines. Fluorescence images and MRI analysis showed that the MGNCs were effectively taken up by the cells. ERB-conjugated MGNCs had an excellent synchronous therapeutic efficacy as a result of therapeutic antibody and NIR laser-induced SPR. Consequently, MGNCs clearly demonstrated selective imaging and treatment of breast cancer simultaneously. |
| 저자 |
이재원, 강진영, 양재문, 허용민, 함승주
|
| 소속 |
연세대 |
| 키워드 |
gold; magnetite; hyperthermia; MRI contrast agent
|
| E-Mail |
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| 원문파일 |
초록 보기 |
