| 학회 |
한국고분자학회 |
| 학술대회 |
2017년 가을 (10/11 ~ 10/13, 제주컨벤션센터) |
| 권호 |
42권 2호 |
| 발표분야 |
고분자가공/복합재료 |
| 제목 |
Fluorogenic detection of biothiols using nanocrystal-thiol interaction |
| 초록 |
Biothiols such as glutathione, cysteine and homocysteine are involved in a wide variety of biological events pertaining to metabolism and diseases, and to this end, quantitative sensing of these molecules from physiological samples is one of the concerns in diagnostic field. In this study, we found that the surface of colloidal semiconductor nanocrystals could be utilized for such pruposes due to binding affinity of thiol moiety toward crystal surface and the close relationship between surface states and fluorescence of nanocrystals. Through introducing oxidants onto nanocrystals, fluorescence-quenchedm ligand-detached nanocrystals with an abundance of available surface binding sites were prepared. these pretreated nanocrystals exhibited fluorescence recovery with respect ro the concentration of biothiols. This presentation will describe detailedcharacterization on optical behaviors along with surface chemistry during sensing of biothiols. |
| 저자 |
장도협1, 김영선1, 김동하2, 안동준3, 김세훈1
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| 소속 |
1한국과학기술(연), 2이화여자대, 3고려대 |
| 키워드 |
Quantum Dot; bio-thiol; hydrogen peroxide
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| E-Mail |
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