| 학회 |
한국재료학회 |
| 학술대회 |
2010년 가을 (11/11 ~ 11/12, 무주리조트) |
| 권호 |
16권 2호 |
| 발표분야 |
D. Health and Biological Materials(생체 및 의용재료) |
| 제목 |
Fabrication of PCL-Gelatin-HAp Fibers for Bone Tissue Engineering Application |
| 초록 |
Electro-spinning of polycaprolactone (PCL), gelatin (GE), a PCL-GE blend and HAp loaded in PCL-GE blend was conducted with the aim of fabricating biodegradable scaffolds for tissue engineering. The process parameters including the concentration of HAp (at three HAp different concentrations: 10%, 30% and 50%) in PCL-GE blends, electrical field and tip-to-collector distance (TCD) were investigated. The miscibility of the PCL-GE blend fibers was examined by differential scanning calorimetry (DSC) and X-ray diffraction (XRD) was used to determine the crystallinity of the membrane. Tensile strength was measured to evaluate the physical properties of the membrane. In addition, the in-vitro cyctotoxicity and proliferation of osteoblast cells on the PCL-GE scaffolds were examined. Based on the combined results of this study, the PCL-GE and PCL-GE-HAp membrane hold great promise for use in tissue engineering applications, especially in bone tissue engineering |
| 저자 |
Ju yeon Chae1, Nguyen Thuy Ba Linh2, Byong-Taek Lee3
|
| 소속 |
1Department of Biomedical Engineering & Materials, 2School of Medicine, 3Soonchunhyang Univ. |
| 키워드 |
electrospinning; PCL; Gelatin; HAp; bone tissue engineering
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| E-Mail |
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