| 초록 |
We developed a new T1 MRI contrast agent using biocompatible manganese oxide (MnO) nanoparticles. When the MnO nanoparticles were injected bolus to a mouse through a tail vein line, the detailed anatomic structures of the brain, kidney, and spinal cord, were depicted in contrast enhanced T1-weighted MRI. Furthermore, functionalized MnO nanoparticles prepared by conjugation with a tumor specific antibody were used for imaging selectively the breast cancer cells in the metastatic brain tumor model. We reported on the fabrication of monodisperse nanoparticles embedded in uniform pore-sized mesoporous silica spheres and PLGA polymers. We fabricated magnetic gold nanoshells consisting of gold nanoshells (for NIR photothermal therapy) that are embedded with Fe3O4 nanoparticles (for MRI contrasting agent), and conjugated them with cancer targeting agent (for targeting). Cancer cells targeted with magnetic gold nanoshells were detectable by a clinical MRI system and rapidly destroyed by exposing them to femtosecond laser pulses of NIR wavelength at a low power. We synthesized Ni/NiO core/shell nanoparticles and applied them to the selective binding and subsequent magnetic separation of histidine-tagged proteins. |
