| 학회 |
한국고분자학회 |
| 학술대회 |
2009년 가을 (10/08 ~ 10/09, 광주과학기술원 오룡관) |
| 권호 |
34권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Effects of theMolecular Weights of PolyvinylpyrrolidoneonRelease Behaviors of Metformin HCl Tablet |
| 초록 |
In this study, metformin HCl, a highly water soluble anti-hyperglycemic agent was prepared into tablet type with PVP of various molecular weights(Mw) to effective oral administration. Because dissolution rate of drug with Mw of PVP becomes decreased as increasing Mw of PVP. We compared the in vitro release behavior of metformin from the tablets according to additives with commercial drug, Diabex ®. The change of structure and crystallinity of tablet by additives were characterized by fourier-transform infrared spectroscopy(FT-IR) and differential scanning calorimeter(DSC). FT-IR and DSC results demonstrate that structure of drug was changed and crystallinity of drug was decreased according to decreasing Mw of PVP. The dissolution rate of metformin HCl from tablet decreased in simulated gastric fluid(pH 1.2) and simulated intestinal fluid(pH 6.8) as increasing K value of PVP. This study suggests Mw of pharmaceutical exipients could effect the metformin HCl release behavior. |
| 저자 |
성경열, 김대성, 김세호, 김용기, 박현진, 김원, 엄신, 이은용, 조은혜, 이동원, 강길선
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| 소속 |
전북대 |
| 키워드 |
Metformin HCl; tablet; PVP; molecular weights; controlled release
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| E-Mail |
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