| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.95 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Characterization and Preparation of Low Molecular Water-soluble Chitosan Nanoparticle for Using as a Biomedical Materials |
| 초록 | Low molecular and water-soluble chitosan nanoparticles (LMWSC-NPs) were prepared by dialysis method as modify the chitosan with hydrophobic and hydrophilic group and investigated the potential as delivery system for gene or hydrophobic drug. The LMWSC-NPs modified hydrophobically would be used to both of intravenous injection and oral administration of hydrophobic drugs due to their adequate size for administration. First, we performed the experiment of electrophoresis, transfection efficiency and cytotoxicity to investigate the potential as a gene carrier. From these results, LMWSC having free-amine group will be useful in the development of safe gene carriers. Also, the surface morphology of hydrophobically modified LMWSC-NPs was identified from the results of TEM and AFM, and its size was 30∼100nm. Using these nanoparticle, we tried the loading of poorly water-soluble drug and evaluated the potential as a drug carrier for anticancer agent. References 1. J.W. Nah, and M.K. Jang, J. Polym. Sci., Part A: Polym. Chem., 2002, 40, 3796. 2. M. Lee, J.W. Nah, Y. Kwon, J.J. Koh, K.S. Ko, S.W. Kim, Pharmaceutical Research 2001, 18, 427. |
| 저자 | 장미경1, 김동곤1, 나재운1, 김태형2 |
| 소속 | 1순천대, 2조선대 |
| 키워드 | LMWSC; hydrophobic drug; nanoparticle; gene |
