| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
의료용 고분자 부문위원회(초청-영어발표/포스터-국문발표 가능) |
| 제목 |
Insulin-immobilized HA/PLGA hybrid nanofiber scaffolds for bone tissue regeneration |
| 초록 |
The development of tissue engineering in the field of orthropaedic surgery is booming. In the present study we have chemically immobilized insulin onto HA nanorods surface. The insulin-immobilized (HA-I) were dispersed into PLGA/THF:DMF solution. The solution was electrospun to prepare the composite nanofibrous scaffolds of PLGA,PLGA/HA and PLGA/HA-I for bone tissue regeneration. After extensive characterization of the composite nanofiber scaffolds by various spectroscopic techniques, PLGA/HA-I and PLGA/HA composite nanofiber scaffolds were subjected to cell studies. The results obtained suggested that the PLGA/HA-I composite nanofiber scaffolds enhanced the proliferation and differentiation of osteoblastic cells. Enhanced osteoblastic cell proliferation by insulin immobilization will open new possibilities for the development of artificial scaffolds for bone tissue regeneration. |
| 저자 |
하이더 아드난, 강인규, 칼리시챈드라굽타
|
| 소속 |
경북대 |
| 키워드 |
Hydroxyapatite; Insulin; Osteoblastic cells
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| E-Mail |
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