| 학회 | 한국공업화학회 |
| 학술대회 | 2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 23권 2호 |
| 발표분야 | 포스터_생체재료 |
| 제목 | Cancer immunotherapy with hMSC based modulator |
| 초록 | Photodynamic therapy (PDT) which generates reactive oxygen species (ROS) has been attracted attention because of ability to kill cancer cells with high therapeutic efficacy. Recently, immunotherapies with nano-based technology have been used to enhance the PDT effect. However, nanotechnology combinated immunotherapies have limitations, short half-life and serious side effects such as normal cell toxicity. To alleviate these problems, we designed the immunotherapy strategy that uses the human mesenchymal stem cell (hMSC) augment polymer and photosensitizer (PS) (hMSC-PP). Due to this strategy, hMSC-PPs can migrate to the lesion sites and avoid the immune system itself. In vivo test, under the laser irradiation to the hMSC-PPs, immune cells are increased at tumor lesion, because pro-inflammatory cytokine levels were increased. Resultingly, tumor growth was inhibited. As a result, hMSC-PP proved their significant potential for the cancer immunotherapy. |
| 저자 | 진민영, 김경섭, 이주영, 한지은, 황희숙, 이종환, 나건 |
| 소속 | 가톨릭대 |
| 키워드 | human mesenchymal stem cell; photosensitizer; immunotherapy; immune modulator; cancer therapy |
