| 학회 | 한국공업화학회 |
| 학술대회 | 2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 23권 2호 |
| 발표분야 | 포스터_생체재료 |
| 제목 | Cholangiocarcinoma immunotherapy using light responsive modulator |
| 초록 | Many studies about effective delivery to cholangiocarcinoma of gemcitabine have been developed. However, delayed diagnosis of cholangiocarcinoma has the problem of low therapeutic effect. There are still difficulties to overcome various problems such as enhancing therapeutic effect and nonspecific normal tissue damage. In this study, we made light reactive modulator loaded gemcitabine to improve the therapeutic efficacy. The release rate of gemcitabine from liposomes was improved approximately 2-fold compared to the non-laser irradiation group due to lipid destruction by reactive oxygen species generated from activated photosensitizers upon laser irradiation. Modulators enter tumor tissue and increase drug release in cancer upon laser irradiation. In addition, modulators recruited various immune cells for effective anti-tumor immunotherapy against cholangiocarcinoma. These modulators are expected to grow into new platforms for drug delivery systems and chemotherapy. |
| 저자 | 이주영, 김다혜, 나건 |
| 소속 | 가톨릭대 |
| 키워드 | Cholangiocarcinoma; Immunotherapy; Photodynamic therapy; Liposome |
