| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
In vivo delivery of anti-KITENIN shRNA complexed with biodegradable PEI-alt-PEG suppressed colon carcinorma established subcutaneously in mice |
| 초록 |
Non-viral gene therapy including polymeric carrier has gained increasing interest as an alternative to viral vectors. In this study, biodegradable gene carrier was synthesized and explored for anti-cancer gene therapy in vitro and in vivo. It has been suggested that specific knockdown of KITENIN expression in colon adenocarcinoma leads to suppression of progression and metastasis of tumor in mice and can be achieved by the delivery of siRNA or shRNA targeting KITENIN. Therefore, Biodegradable gene carrier-mediated delivery of anti-KITENIN shRNA has been developed for efficient cancer gene therapy. In vivo systemic delivery of nanoparticles demonstrated the drastic suppressions of tumor growth by PEI-PEG over time. Our on-going study suggested that incorporation of tumor-specific ligands would improve its efficacy greatly. |
| 저자 |
박인규1, 김경근2, Dhananjay Jere3, 조종수3, 정익주4
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| 소속 |
1전남대 의대 의생명과학교실 / 전남대 기초의과학연구센터, 2전남대 기초의과학연구센터, 3서울대 농생명공학부, 4전남대 기초의과학연구센터 / 전남대 의대 혈액종양내과 |
| 키워드 |
Biodegradable gene carrier; anti-metastasis; colon cancer
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| E-Mail |
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