| 학회 |
한국고분자학회 |
| 학술대회 |
2011년 가을 (10/06 ~ 10/07, 김대중 컨벤션센터) |
| 권호 |
36권 2호 |
| 발표분야 |
대학원생 구두발표 |
| 제목 |
Well-Defined DNA-Mimic Brush Polymers Bearing Adenine Moieties: Synthesis, Layer-by-Layer Self-Assembly, and Biocompatibility |
| 초록 |
Two new DNA-mimicking brush polymers were synthesized: poly[oxy(11-(3-(9-adeninyl)propionato)-undecanyl-1-thiomethyl)ethylene] (PECH-AP) and poly[oxy(11-(5-(9-adenylethyloxy)-4-oxopentanoato)undecanyl-1-thiomethyl)ethylene] (PECH-AS). These polymers were found to be thermally stable up to 220 °C and could be applied easily by conventional coating processes to produce good quality films. Interestingly, both brush polymers formed molecular multi-bilayer structures to provide an adenine-rich surface. Despite the structural similarities, PECH-AS surprisingly exhibited higher hydrophilicity and better water sorption properties than PECH-AP. These differences were attributed to the chemical structures in the bristles of the polymers. The adenine-rich surfaces of the polymer films demonstrated selective protein adsorption, suppressed bacterial adherence, facilitated HEp-2 cell adhesion, and exhibited good biocompatibility in mice. |
| 저자 |
김진철1, 정정운1, 노예철1, 김미희1, 안병철1, 권원상1, 김경태1, 고용기1, 정성민1, 권경호1, 김영용1, 김희수2, 김익정2, 김정란2, 이문호1
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| 소속 |
1포항공대, 2동국대 |
| 키워드 |
biopolymer; brush polymer; DNA-mimic polymer; self-assemly polymer; bio-compatible polymer
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| E-Mail |
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