| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 봄 (04/14 ~ 04/15, 전경련회관) |
| 권호 | 30권 1호, p.93 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Nanotechnology-based photodynamic therapy of neovascular disease by supramolecular nanocarrier loaded with dendritic photosensitizer |
| 초록 | Photodynamic therapy (PDT) has been developed and applied for the treatment of exudative age-related macular degeneration (AMD), a condition caused by choroidal neovascularization (CNV) and a major cause of legal blindness in developed countries. PDT works by activating the photosensitizer (PS) by light irradiation to induce involution of the CNV through reactive oxygen species. The efficacy of the PDT would much improve if the damage to the healthy retina could be avoided. Despite numerous efforts directed to exploring effective targeting, it is imperative that a fraction of the PS distributes to the retinal and choroidal vessels and skin, thereby damaging the normal retinal tissue and skin during PDT. We developed a novel strategy of PDT, exploiting the unique properties of supramolecular nanocarrier, polyion complex (PIC) micelle, and a novel starburst dendritic photosensitizer, dendrimer porphyrin (DP). Ionic DP is one of the promising materials, because the DP exhibits high solubility to aqueous medium and has a high quantum yield for singlet oxygen generation. Furthermore, charged ion surface can form PIC micelles by an electrostatic interaction by an addition of oppositely charged block copolymer. These types of PIC micelles with PEG shell were demonstrated to accumulate effectively and specifically in solid tumor tissue. Here, we demonstrate that PIC micelle encapsulating DP effectively accumulates into the CNV lesions and produces remarkably distinct photodynamic effect with minimal unfavorable phototoxicity to the healthy retinal and skin tissue. Our results provide a basis for developing a novel therapeutic approach of PDT using the nanomolecular devices. References 1. N. Nishiyama et al. Bioconjugate Chem. 14, 58-66 (2003). 2. H. R. Stapert et al. Langmuir, 16, 8182-8188 (2000). 3. W.-D. Jang et al. Angew. Chem., Int. Ed. 44, 419-423 (2005) |
| 저자 | 장우동1, Fumitaka Tasaka2, Ryuichi Ideta3, Yasuo Yanagi1, Yasuhiro Tamaki1, Nobuhiro Nishiyama1, Kazunori Kataoka1 |
| 소속 | 1The Univ. of Tokyo, 2Santen Pharmaceutical Co., 3Ltd. |
| 키워드 | Dendrimer; Photosensitizer; Photodynamic Therapy |
