| 초록 |
The aim for this study is to develop a drug delivery carrier with a specific drug release profile towards tumor cells based on the fact that tumor cells have lower pH and higher concentration of a reducing agent than normal cells. Hydrazone bond has been used as a pH sensitive linker that is stable at pH7.4 but unstable at pH5.0. Doxorubicin (DOX) was conjugated on poly(aspartyl hydrazide) backbone with hydrazone bond. N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP) crosslinker grafted on the backbone formed a disulfide bond in a normal cell, but the disulfide bond was dissociated in a tumor cell. In a normal cell drugs were released with only disregarded amount, but in a tumor cell, drugs were rapidly released as a consequence of breaking of hydrazone bonds and disulfide bonds. Characterization of the dual sensitive particle was fully investigated, and drug release profile was also evaluated. |
