| 학회 |
한국화학공학회 |
| 학술대회 |
2013년 봄 (04/24 ~ 04/26, 광주 김대중컨벤션센터) |
| 권호 |
19권 1호, p.62 |
| 발표분야 |
고분자 |
| 제목 |
A pH and reduction dual responsive drug delivery carrier based on poly(amino acid) derivatives for tumor treatment |
| 초록 |
This study was conducted to develop a drug delivery carrier with a specific drug release profile towards tumor cells based on the fact that tumor cells have lower pH and higher concentration of a reducing agent than normal cells. Hydrazone bond was used as a pH sensitive linker that is stable at pH7.4 but unstable at pH5.0. Doxorubicin (DOX) and methoxy poly ethylene glycol (mPEG) were conjugated on poly(aspartyl hydrazide) backbone with hydrazone bond. N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP) crosslinker grafted on the backbone formed a disulfide bond in a normal cell, but the disulfide bond was dissociated in a tumor cell. In a normal cell drugs were released with only disregarded amount, but in a tumor cell, drugs were rapidly released as a consequence of breaking of hydrazone bonds and disulfide bonds. Characterization of the dual sensitive particle was fully investigated and drug release profile was also evaluated. |
| 저자 |
김소은, 박찬우, 김종득
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| 소속 |
한국과학기술원 |
| 키워드 |
disulfide bond; pH sensitivity; drug delivery carrier; Poly (amino acid) derivatives
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| E-Mail |
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| 원문파일 |
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