| 학회 | 한국화학공학회 |
| 학술대회 | 2005년 가을 (10/21 ~ 10/22, 인하대학교) |
| 권호 | 11권 2호, p.1687 |
| 발표분야 | 고분자 |
| 제목 | Novel amphiphilic poly(amino acid) derivatives for intracellular pH-sensitive drug carrier |
| 초록 | Recently, amino acid-based polymers have become one of the most important biomaterials for drug delivery systems due to biocompatible and biodegradable properties. Polymers that respond to a small change in pH have a wide range of applications. In particular, much attention has been paid to pH-sensitive drug delivery systems such as intracellular endosomal drug release and tumor targeting delivery. 1-(3-Aminopropyl)imidazole has imidazole ring like histidine and primary amine to react with succinimide group of polysuccinimide(PSI). So, we prepared new pH-sensitively modified poly(amino acid) derivatives for pH-sensitive intracellular drug delivery carrier by introducing 1-(3-aminopropyl)imidazole and hydrophilic PEG-NH2 to PSI, and characterized their pH-sensitive properties. The polymers showed sharp pH-responsive abilities according to small pH change (pH 7 → 6.8). They formed nano-aggregates in aqueous solution above pH 7 by hydrophobic imidazole interaction, but dissociated below pH 7 by ionization of imidazole rings. They also had high buffering properties at endosomal pH range. |
| 저자 | 서광원, 김덕준 |
| 소속 | 성균관대 |
| 키워드 | pH-sensitive; poly(amino acid); nanopaticle |
| 원문파일 | 초록 보기 |
