| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Albumin-coated liposomes containing doxorubicin and their binding property of blood plasma protein |
| 초록 |
Liposomes are nano scanle vesicles that can be used as chemical or biological drug carrier. However, conventional liposomes are plagued by rapid opsonization, making their circulation time in bloodstream to be shortened. In this study, cationic liposome of which surface was coated with bovine serum albumin (BSA) were prepared via electrostatic interaction between cationic liposomes and BSA molecules at higher pH than pI of BSA. BSA on the liposomal surface was denatured by thermal treatment of the prepared liposomes. The mean particle diameter of both conventional and cationic liposome were about 104±1 nm. On the other hand, BSA-coated cationic liposomes (BCL) had a mean particle diameter of 109±1 nm. The mean particle diameter of the BCL put in blood plasma did not increase indicating that the BCL was more stable than conventional and cationic liposomes. These results suggest that BCL can be used as a long-circulating liposomes in bloodstream. |
| 저자 |
김성규1, 정석현1, 성하수1, 지상철2, 신병철1
|
| 소속 |
1한국화학(연), 2성균관대 |
| 키워드 |
Liposome; Albumin; Denaturation; Protein binding; Doxorubicin
|
| E-Mail |
|
