| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Synthesis of water soluble PEGylated magnetic complexes using mPEG-fatty acid for biomedical applications |
| 초록 |
We report the successful fabrication of the various types of water-soluble PEGylated magnetic complexes (PMCs) for magnetism related biomedical applications. Various types of PMCs were synthesized and tested to accomplish phase transfer from organic to aqueous phase using monomethoxy polyethylene glycol (mPEG)-fatty acid amphiphilic block copolymers (PFs) through conjugation of the hydroxyl group of mPEG with the carboxyl group of fatty acids. We also carefully investigate their colloidal stabilities in aqueous phase according to the ratio of hydrophilic and hydrophobic lengths relying on different types of fatty acids. Synthesized PMCs clearly demonstrated high magnetic sensitivity under magnetic field as magnetic resonance (MR) contrast agents. Furthermore, PMCs exhibited sufficient cell viabilities and excellent cell affinities in an in-vitro model. |
| 저자 |
임은경, 양재문, 박미예, 박요셉, 서진석, 윤호근, 허용민, 함승주
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| 소속 |
연세대 |
| 키워드 |
Fatty acid; Magnetic resonance image; Magnetic nanocrystal; monomethoxy polyethylene glycol (mPEG); Magnetic complex
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| E-Mail |
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