| 초록 |
Due to nontoxic characteristic and gel-forming ability of poly(vinyl alcohol) (PVA), recently, PVA hydrogel has been widely used as drug delivery materials. Syndiotacticity-rich PVA (s-PVA) has been known to have different properties as compared with atactic PVA due to an increased intermolecular hydrogen bonding between the adjacent hydroxyl groups. To maximize physical properties of PVA, syndiotacticity, degree of saponification (DS), and molecular weight should be increased. In this study, for the preparation of water-soluble s-PVA, vinyl pivalate and vinyl acetate were copolymerized at 40 ℃ with 2,2'-azobis(2,4-dimethylvaleronitrile), and the specimen polymerized was saponified. Stable s-PVA hydrogels have been prepared by using freezing-thawing method for drug delivery systems. These s-PVA hydrogels prepared are suitable for protein/peptide drug delivery since formation of the hydrogel does not require any crosslinking agents or other adjuvants. Bovine serum albumin (BSA), as a model protein drug, is incorporated into the PVA gels. The drug release with s-PVA hydrogels containing BSA solution was studied under various conditions: PVA concentration for gelation, DS and syndiotacticity of PVA. Effects of molecular parameters affecting the protein drug loading efficiency of PVA hydrogel were investigated.
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