| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 봄 (04/04 ~ 04/06, 대전컨벤션센터) |
| 권호 |
43권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
In Vitro and In Vivo Evaluation of Dual Growth Factor-Loaded Alginate/Hyaluronic Acid Hydrogel for the Treatment of Liver Cirrhosis |
| 초록 |
Liver cirrhosis is defined as irreversible end result of fibrous scarring and making it difficult for the liver to function. In this study, we prepared growth factor (hepatocyte growth factor and/or basic fibroblast growth factor)-loaded in situ gelling alginate/hyaluronic acid hydrogels. The growth factor-loaded ALG/HA hydrogels were investigated for their in vitro hepatocytic differentiation of adipose stem cells (ASCs) and in vivo animal study using an acute cirrhosis BALB/c mice model. The growth factors were continuously released from the hydrogels for more than 35 days. The dual HGF/bFGF-loaded hydrogel showed the enhanced hepatocytic differentiation of ASCs compared to the hydrogels with single growth factor loading or those without growth factor. The dual growth factor-loaded ALG/HA hydrogel also allowed greatly enhanced treatment effect for the liver cirrhosis. From the results, dual HGF/bFGF-loaded ALG/HA hydrogel may be a good system for the treatment of liver cirrhosis. |
| 저자 |
최소리1, 김태호1, 이재선2, 오세행3, 전대원2, 이진호1
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| 소속 |
1한남대, 2한양대, 3단국대 |
| 키워드 |
Alginate; Hyaluronic acid; Growth factor; Hydrogel
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| E-Mail |
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