| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
BMP-2 Concentration Effect on Bone Regeneration: In vitro and In vivo Studies Using PLGA Beads with Different BMP-2 Release Pattern |
| 초록 |
The immobilization of bioactive molecules (e.g., growth factor) onto scaffolds is considered as an essential requirement for enhanced tissue regeneration. In recent, the regulation of release rate of the bioactive molecules from matrices has been also gained increasing interest for more sophisticated target tissue/organ regeneration. In this study, we developed porous beads with different surface pore size (micro-sized, nano-sized, and dense) which may control the release pattern of bioactive molecules immobilized in the beads by the different permeation rate of bioactive molecules through the surface pores. Their morphology, BMP-2 release profile, osteogenic differentiation behavior (in vitro); and bone regeneration potential (in vivo) were compared. |
| 저자 |
오세행1, 이진호2, 변준호3, 박진호3, 김호용1
|
| 소속 |
1단국대, 2한남대, 3경상대 |
| 키워드 |
porous beads; bioactive molecules; osteogenic differentiation
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| E-Mail |
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