| 학회 |
한국화학공학회 |
| 학술대회 |
2006년 가을 (10/27 ~ 10/28, 고려대학교) |
| 권호 |
12권 2호, p.1654 |
| 발표분야 |
분리기술 |
| 제목 |
Application of 1-hexyl-3-methylimidazolium tetrafluoroborate [Hmim][BF4] as a mobile phase additive to separate acidic stereoisomers in simulated moving bed chromatography |
| 초록 |
Ionic liquids have been recently well-known as a “green solvent” in various fields of chemistry as well as mobile phase additives in liquid chromatography. To study the application of ionic liquids as mobile phase additives in Simulated Moving Bed chromatography-a technology of continuous chromatography, 1-hexyl-3-methyl-imidazolium tetrafluoroborate [Hmim][BF4] was added to binary mobile phase solution (water/methanol) for separation of a mixture of 2 acidic stereoisomeres. The 4-zone SMB chromatograph composed with 8 columns (C18, 25μm, 1.0x10 cm) was used. Frontal analysis experiment results showed that using [hmim][BF4] as mobile phase additive conducted to an apparent improvement of adsorption behavior. The ionic liquid ([Hmim][BF4]) therefore could be used as an additive of mobile phase to separate anionic solutes and was useful for enhancing the efficiency of SMB chromatography. |
| 저자 |
레타이황, 이주원, 김정근, 구윤모
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| 소속 |
인하대 |
| 키워드 |
ionic liquid; [hmim][BF4]; simulated moving bed; Hydroxybenzoic acid
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| E-Mail |
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| 원문파일 |
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