| 초록 |
Caesalpinia sappan L. (Leguminosae) is an oriental medicinal herb distributed in China and Taiwan, and its heartwood has been traditionally used as an analgesic, a therapy for thrombosis or tumor etc.. that showed various anti-inflammatory activity, and other biological properties. We studied the effect of Caesalpinia sappan methanol extract.Our results suggest that Caesalpinia sappan methanol extract can inhibit NO and PGE2 productions through suppression of LPS-induced iNOS and COX-2 expression. Because COX-2- or iNOS-dependent mechanisms are involved in inflammation and tumor progression, our findings provide a new uncovering mechanism responsible for anti-inflammatory and antitumor effects of Caesalpinia sappan. |
