| 초록 |
In the study, gelatin fibers were successfully produced with the use of the Electrospinning technique. A fluorinated alcohol of 2,2,2-trifluoroethanol (TFE) was used as the dissolving solvent. The morphology of the electrospinning gelatin fibers was found to be dependent on the alteration of gelatin concentration ranging from 3 wt/v% to 15wt/v% at 3% increment intervals. Based on the electrospinning gelatin fibers obtained, 10wt/v% gelatin/TFE solution was selected and mixed 10wt/v% poly(L-lactide-co-ε-caprolactone)(PLCL) in TFE at a ratio 10:90, 30:70, 50:50, 70:30, and 90:10. Contact-angle measurement and tensile tests indicated that the gelatin/PLCL complex fibrous membrane exhibited improved mechanical properties as well as more favorable wett ability than that obtained from either gelatin and PLCL alone. The gelatin/PLCL fibrous membranes were further investigated as a promising scaffold for bone marrow mononuclear cells(BMMNCs) culture. The results suggest the potential of using composite gelatin/PLCL fibous scaffolds for tissue engineering. |
