| 초록 |
Poly(ε-caprolactone) (PCL) is a widely used polymer in the biomedical field due to its good biocompatibility, biodegradability and permeability. It has also been shown that many different cells show excellent cell attachment and growth on this polymer, making it a well-suited material to prepare tissue engineering scaffolds. In this study, PCL nanofibrous scaffolds (NFS) were prepared by electrospinning. Briefly, The polymer solution (8, 12wt/v%) was placed in a vertically fixed 10ml glass syringe fitted with a 1.3cm, 28-G needle. In vitro/vivo degradation studies of scaffolds was investigated as a function of radiation dose. The chondrocytes seeded NFSs were implanted into nude mice subcutaneously to monitor the in vivo degradation. In addition, they were degraded in vitro in phosphate buffer saline (PBS, pH 7.4) up to 15 weeks to examine the radiation effects of PCL NFSs. |
