| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
[생물공학] 바이오테크놀로지 발전 30년 최첨단 현황 |
| 제목 |
Metabolic Engineering for Utilizing Various Carbon Sources |
| 초록 |
The development of industrial strains that can efficiently utilize various carbon sources has been emphasized in metabolic engineering because cheaper carbon source should be utilized in biorefinery. In case of glucose, overflow metabolism is the main problem in because high amounts of byproducts are produced. This can be significantly reduced if the glucose uptake rate is regulated in various strains. To utilize lignocellulosic biomass, the strain must be able to co-utilize glucose and xylose. This can be resolved by minimizing carbon catabolic repression (CCR), which is regulated by phosphotransferase system (PTS). Disruption of PTS was not enough so that further engineering to reduce metabolic burden was applied. Fourth generation carbon source, C1 gas, can also be utilized for PHB production. Useful metabolic engineering strategy for utilizing C1 gas in industrial strain will also presented. |
| 저자 |
오민규 |
| 소속 |
고려대 |
| 키워드 |
Metabolic engineering; Carbon source;
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| E-Mail |
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