| 초록 |
Proteins in the presence of cells, can be categorized, depending on their biological functions and their locations, i) extracellular matrix as an outer cellular membranes, ii) transmembrane proteins (TPs), regulating the trafficking of biological substances across cellular membranes, and iii) cytoskeleton fibril proteins located in cytoplasm. At the reaction front of the cellular membranes, the inner, outer and trans- membrane proteins are physically cross-over. Due to the complexity of the protein-incorporated in the membrane, very limited studies are available. We investigated that the protein interactions with the biomimetic membranes at outer, inserted, and inner membrane structures independently as a model study. X-ray and neutron reflection measurements could provide the detailed structural information of, formation of membrane structures, protein binding and fibril formation, for ECM proteins, transmembrane proteins, and cytoplasmic cytoskeleton proteins. These information in molecular level will compare to the macroscopic information from optical microscopy. |
