| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
대학원생 구두발표 |
| 제목 |
Cytocompatible self-assembling hydrogel and its modular modification using highly selective host-guest chemistry |
| 초록 |
Self-assembling hyaluronic acid (HA) hydrogel (CB[6]/DAH-HA hydrogel) was successfully developed using highly specific host-guest chemistry with cucurbit[6]uril-modified HA (CB[6]-HA) and 1, 6-diaminohexane-modified HA (DAH-HA). CB[6]/DAH-HA hydrogel could be easily decorated with various functional groups by facile and modular modifications maintaining the structural integrity of the hydrogels. According to live/dead cell assay with calcein AM and ethidium homodimer-1, more than 90% of NIH3T3 (mouse fibroblast) cells in the hydrogels emitted the green fluorescence of live signal even after encapsulation for 3 days. Moreover, the facile modular modification of CB[6]/DAH-HA hydrogel encapsulating NIH3T3 cells with cyclic(RGDyK)-CB[6] resulted in dramatically enhanced cell adhesion and proliferation. The novel self-assembling cytocompatible CB[6]/DAH-HA hydrogel system would be exploited as in situ forming hydrogels for various cell therapy and tissue engineering applications. |
| 저자 |
정현태, 박경민, 양정아, 한세광, 김기문
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| 소속 |
POSTECH |
| 키워드 |
Hyaluronic acid; Cucurbituril; Host-guest chemistry; Hydrogel; Tissue engineering
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| E-Mail |
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