| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 봄 (04/10 ~ 04/12, 부산컨벤션센터(BEXCO)) |
| 권호 |
44권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Degradation-regulatable architectured implantable macroporous scaffold for the spatiotemporal modulation of immunosuppressive microenvironment and enhanced combination cancer immunotherapy |
| 초록 |
A degradation-regulatable architectured implantable macroporous scaffold (Dr-AIMS) is designed to act as a local drug delivery reservoir, modulating the immunosuppressive tumor microenvironment (TME) and activating T-cell-based anti-tumor immunity as well. The Dr-AIMS is fabricated by the crosslink of methacrylate-modified hyauronic acid under frozen state to form the interconnected macroprorous architacture with varied blending ratios, the degradation can be regulated with 10-28 days after implantation in mice. The sustained and localized supply of immunomodulatory drugs from Dr-AIMS facilitated the depletion of MDSCs and M2-like macrophages simultaneously within the tumor tissues, converting immunosuppressive TME into anti-tumor immunity niches. Also, systemic anti-tumor immunity was generated with 10-fold reduced doses, resulting in the prolonged survival of mice after surgery of incompletely removed tumor. |
| 저자 |
RENLONG, 임용택, 신일우, 진승모, 이상남, 박건희, 배준한
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| 소속 |
성균관대 |
| 키워드 |
Tumor microenvironment; Combination immunotherapy; Implantable scaffold; Regulatable degradation.
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| E-Mail |
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