| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Synthesis and Characterization of PLGA/PEG Block Copolymer Hydrogels for Tissue Expander Application |
| 초록 |
A series of biodegradable block copolymer hydrogels having a delayed swelling property were synthesized and evaluated for tissue expansion applications. The hydrogels were synthesized via radical crosslinking reaction of poly (ethylene glycol) (PEG) diacrylate and PLGA-PEG-PLGA diacrylate which act as hydrophilic crosslinker and a swelling/degradation controller, respectively. Various PLGA-PEG-PLGA tri-block copolymers with different LA/GL ratios and different PLGA block lengths were synthesized, and they were modified to have terminal acrylate groups as confirmed by FT-IR and 1H-NMR measurements. The in vitro degradation tests showed that the delayed swelling of the hydrogels could be modulated by varying the chemical composition of the biodegradable crosslinker, and the lag time before swelling ranged from one week to five weeks. |
| 저자 |
임수진1, Yourong Fu2, John Garner3, Kinam park2, 허강무3
|
| 소속 |
1충남대, 2Akina, 3Inc |
| 키워드 |
Biodegradable hydrogels; PLGA; PEG; tissue expander
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| E-Mail |
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