| 초록 |
5-Aminovaleric acid (5AVA) is an important five-carbon platform chemical especially for synthesis of polymers and other industrially valuable chemicals. Employment of lysine 2-monooxygenase encoded by the davB gene and 5-aminovaleramidase encoded by the davA gene has been successful for enzymatic conversion of L-lysine to 5AVA. In addition, a recombinant Escherichia coli strain expressing the davB and davA genes was developed for the bioconversion of L-lysine to 5AVA. Corynebacterium glutamicum, an efficient L-lysine producing microorganism, is a highly promising platform to develop of direct fermentative production of 5AVA using L-lysine as a precursor for 5AVA. In this report, metabolic engineering was done in C.glutamicum to enhance the fermentative production of 5AVA from glucose. This work was supported by the Technology Development Program to solve climate changes (Systems Metabolic Engineering for Biorefineries) (NRF-2012M1A2A2026556 and NRF-2012M1A2A2026557) from the Ministry of Science, ICT through the National Research Foundation (NRF) of Korea and NRF grant funded by the MSIP (NRF-2016R1A2B4008707). |
