| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Effect of PLGA/silk fibroin Hybrid Films on Attachment and Proliferation of Schwann cells |
| 초록 |
Poly(lactic-co-glycolic acid) (PLGA) is a biodegradable synthetic polymer with acceptable mechanical strength and well-controlled degradation rate. Also, it can be easily fabricated into many shapes. Silk fibroin contains powerful bioactive molecules. We fabricated natural /synthetic hybrid films using 0, 10, 20, 40 and 80 wt% of silk fibroin. Schwann cells (SCs) were seeded on PLGA/silk fibroin hybrid film and confirmed the effects of adhesion and proliferation on SCs according to content of silk fibroin. In this study, we confirmed that specific 10 and 20 wt% silk fibroin in PLGA/silk fibroin hybrid films was superior to adhesion and proliferation of SCs content of silk fibroin such as 40 and 80 wt% could not help cell growth and proliferation. These results suggest that silk fibroin provide suitable surface to neural cells and proper content affect on culture condition to improve cell adhesion and proliferation. This research was supported by WCU(R31-20029) and SCRC (SC4110). |
| 저자 |
김혜린1, 유한나2, 박현진2, 김용기2, 정수미2, 엄신2, 이동원2, 강길선2
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| 소속 |
1전북대, 2고분자나노공학과 |
| 키워드 |
Silk fibroin; Poly(lactic-co-glycolic acid)(PLGA); Schwann cell; Hybrid film; Tissue engineering
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| E-Mail |
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