| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Synthesis and characterization of methacrylated hexanoyl glycol chitosan as a photo-crosslinkable thermogelling biomaterial |
| 초록 |
Thermogelling polymers that undergo thermo-responsive sol-gel transition in aqueous media have been studied for biomedical application. In this work, we synthesized hexanoyl glycol chitosan (HGC) as a thermogelling polymer by chemical modification of glycol chitosan using hexanoic anhydride. The HGC (36% of degree of substitution, 4wt%) showed a sol-gel transition temperature around 32 ℃. In order to introduce a chemically cross-linkable thermogelling polymer, we synthesized methacrylated HGCs (M-HGCs) by chemical modification of HGC with glycidyl methacrylate. The degree of methacrylation was controlled to have a range of 3.6%~19.5% by varying the feed ratio of reactants. The sol-gel transition temperature of M-HGC slightly decreased due to the presence of hydrophobic methacryl groups. M-HGC could form thermogel and also stable chemical gel with enhanced mechanical property by UV exposure. Photo-crosslinkable thermogelling M-HGC hydrogels would be useful for biomedical application. |
| 저자 |
조익성1, 조명옥1, 이정정1, 강선웅2, 허강무1
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| 소속 |
1충남대, 2안전성평가(연) |
| 키워드 |
Glycol chitosan; Thermogelling polymer; Photo-crosslinking
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| E-Mail |
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