| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 봄 (04/08 ~ 04/10, 대전컨벤션센터) |
| 권호 |
40권 1호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Curcumin loaded micelles from acid degradable block copolymers having pendant acetal linkages for anticancer activity in intracellular cancer |
| 초록 |
Acid degradable curcumin encapsulated micelles were designed using degradable block copolymers having pendant acetal linkages and investigated their triggered intracellular release behavior in cancer cells. The self assembly behavior of formation of micelles is caused by the nature of hydrophilic poly(ethylene glycol) and hydrophobic pendant acetal groups grafted onto poly(hydroxyethyl methacrylate). The corresponding block copolymer exhibited high biocompatibility towards normal fibroblast cell line. Due to high concentration of acidic pH present in the intracellular space of cancer cells, the enhanced anticancer activity was obtained by the destabilization of pendant acetal chains in the core of micelles under pH response. The pH responsive micelles showed high cellular uptake, and high anticancer activity results suggest that the pH responsive degradable block copolymer micelles offer versatility for targeted drug release of hydrophobic drugs in cancer therapy. |
| 저자 |
라오, 하창식
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| 소속 |
부산대 |
| 키워드 |
self assembly; micelles; curcumin; intracellular drug release
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| E-Mail |
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