| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 가을 (10/26 ~ 10/28, 제주국제컨벤션센터(ICCJEJU)) |
| 권호 |
20권 2호 |
| 발표분야 |
고분자_포스터 |
| 제목 |
pH-responsive polymeric micelles with acid-labile ketal cross-link for drug delivery |
| 초록 |
Micelles of amphiphilic block copolymer, poly(polyethylene glycol methyl ether methacrylate)-block-poly(styrene-alt-maleic anhydride)-block-poly(styrene) (PEGMA-b-PSMA-b-PS), prepared via the reversible addition-fragmentation chain transfer (RAFT) polymerization were cross-linked by amidation process of a degradable cross-linker and carboxylic acid group functional block copolymer. High doxorubicin (DOX) loading capacities (70% wt) were obtained. Core cross-linked micelles illustrated good stability under physiological condition but disassociated immediately under acidic pH. TEM images showed spherical shapes of DOX loaded cross-linked micelles with average hydrodynamic diameter of 67 nm. The DOX release experiments indicated a rapid DOX release at pH 5.0 compared to pH 7.4. The MTT assay demonstrated that the DOX loaded cross-linked micelles exhibited a high antitumor activity towards HepG2 cancer cells. |
| 저자 |
반욱현, 임권택, 김용훈, 이상호, 박요한, Cuong M.Q. Le, Shabrina Aufar Salma
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| 소속 |
부경대 |
| 키워드 |
micelle; drug delivery; RAFT
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| E-Mail |
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