| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 가을 (11/08 ~ 11/10, 부산 벡스코(BEXCO)) |
| 권호 |
21권 2호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
ALP Sensitive Fluorescence Probe of Cyclodextrin Modified Carbon dots for Cancer Detection |
| 초록 |
Specific host-guest recognition and pH sensitive assay for tumor triggered fluorescent assay for monitoring cellular alkaline phosphatase(ALP) activity in coated surface and aqueous state were prepared in this study by crosslinking of cyclodextrin (β-CD)/boronic acid(BA) conjugated fluorescent hyaluronic acid [FNP(HA)] and fluorescent polydopamine [FNP(pDA)] by boronic ester complex (C-FNP). ALP level be used to be 30.125 to 1000 U/L then can specific recover under pH shock due to the cleavage of diol bond between β-CD and BA affecting release of NP from the fluorescent system. Thus, this fluorescence sensor system can be applied to broaden the monitoring ALP and cancer diagnosis in clinical practice in coated surface and aqueous state. This was supported by Korea National University of Transportation in 2017. |
| 저자 |
김영광, 원현정, 박성영, 이기백
|
| 소속 |
한국교통대 |
| 키워드 |
Alkaline phosphatase; Coated surfaces; Cyclodextrin; Fluorescent nanoparticels; Quenching effect; Biosensor
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| E-Mail |
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