| 초록 |
Protein drugs have a majority of medicine due to advances in biotechnology. However, the inherent instability of proteins in the gastro-intestinal tract and short blood half-life, it should be administered parenterally. Recently, injectable in situ forming drug delivery systems has been focused on an attractive alternative to microspheres and implants as parenteral depot system due to their a number of advantages such as ease of administration, diverse application, and simpleformulation. In this study, we synthesized biodegradable thermosensitive poly(organophosphazene) gels bearing α-amino-ω-methoxy poly(ethylene glycol) (AMPEG), and various amino acid esters, and characterized them. Protein release behaviors from poly(organophosphazene) gels under physiological condition were different by polymer composition, kind of substituted amino acid ester and drug. From optimum condition, bovine serum albumin (BSA) was released constantly for 32 days. |
