| 초록 |
We introduced a tumor-targeting fluorescent nanogel for controlled release of doxorubicin and nitric oxide under cancer environment, allowing for fluorescence on. HA was carbonized to form FNP, then conjugated with t-butyl nitrite to synthesize FNP(HA)-SNO-DA, and carbixylphenylboronic acid was conjugated with Lactose-modified Chitosan to create Chitlac-BOH. FNP(HA)-SNO-DA and Chitlac-BOH were cross-linked to synthesize F-nanogel and the loaded doxorubicin. Under acidic condition, DOX and NO were released from DOX-loaded F-nanogels (DOX) owing to pH-sensitive borate ester bond and the presence hyaluronidase enzyme. The pH and HAase conditions in cancer cell environment can be used to selectively control the DOX and NO release. Therefore, this excellent pH-responsive F-nanogel (DOX) can be applied for targeted and controllable drug and NO co-delivery bioimaging system for anticancer applications. This work was supported by Korea National University of Transportation in 2018. |
