| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 봄 (04/10 ~ 04/11, 대전 컨벤션센터) |
| 권호 |
39권 1호 |
| 발표분야 |
고분자합성 |
| 제목 |
pH Responsive Carboxylic Acid Functionalized SBA-15 for Controlled Drug Delivery |
| 초록 |
SBA-15 nano valve having high amount of carboxylic acid has been synthesized via surfactant assisted sol-gel methodology and post modification process. Modified SBA-15 has been tailored as a smart pH responsive controlled release system by the insertion of N-[3-(Trimethoxysilyl)propyl]aniline (TMSPA) at the pore opening before extracting the surfactant and further grafted with 3-(triethoxypropyl)succinic anhydride (PTSA) and further hydrolyzed to carboxylic acid in water on the inner surfaces of the pore channels. 5-fluorouracil and famotidine have been loaded in to the modified channels there after β-cyclodextrin has been introduced as the gatekeeper to make the material as pH responsive drug delivery system. The drug delivery has been carried out under invitro condition at a pH 4 and the amount of drug released from the nano valve systems where monitored by UV-Vis spectroscopy under regular intervals. |
| 저자 |
수렌드란, 매튜 아니쉬, 하창식
|
| 소속 |
부산대 |
| 키워드 |
nanovalve; pH responsive; drug delivery
|
| E-Mail |
|
