| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Preparation of cross-linked cartilage acellular matrix film for anti-adhesion |
| 초록 |
In this work, We chose cartilage acellular matrix (called CAM) as a promising anti-adhesive material because CAM effectively inhibits the formation of blood vessels. We made biodegradable poly(caprolactone-r-lactide-r-glycolide) copolymer (called PCLG) cross-linker to control degradation period and mechanical properties. We made cross-linked CAM/PCLG (Cx-CP) film and treated by heating. First, the Cx-CP film revealed we controlled mechanical properties through tensile strength, contact angle, biodegradation. Next, We confirmed that the cells rarely attached to Cx-CP film through fluorescence and SEM image and do not proliferated through MTT assay compared to control group. We confirmed that the higher the cross-linker ratio until 50% of total ratio, the better the anti-adhesion effect through staining analysis. Finally, we confirmed that we developed suitable anti-adhesive film through various in vitro and in vivo experiments. |
| 저자 |
박준영, 강태웅, 주현진, 김민주, 민병현, 김문석
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| 소속 |
아주대 |
| 키워드 |
acellular matrix; cross-linking; anti-adhesion
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| E-Mail |
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