| 초록 |
Recently a new-generation biodegradable stent has been practically developed and commercialized. The biodegradable polymers such as poly(L-lactic acid) (PLLA) are completely decomposed in the body within 2-3 years. However, since PLLA do not have X-ray absorption property, the biodegradable polymer stents were not able to be visualized in X-ray based imaging devices. Thus it is difficult to place the stent at the correct site during percutaneous coronary intervention if it is not possible to obtain a clear image of the vascular stent. Additionally, acidic byproducts resulting from the degradation of polyester polymers cause inflammation in the surrounding tissues. In this study, we developed a radio-opaque bioabsorbable stent with an anti-inflammatory effect by the use of radio-opaque core-shell nanoparticles. To synthesize the radio-opaque nanoparticle, X-ray imagable metal nanoparticles were shielded with ceramic oxide shell to add the ability to neutralize the acidic environment. |
